Research Vision
- To leverage the power of synthetic biology to probe basic questions in digestive diseases.
- To translate genetic circuit design platforms and research findings into smart living diagnostic and therapeutic applications, especially for gut microbiota-related diseases.
SMART living cells-treat disease in new ways
❶ Sensing
High-throughput mining of genetic elements;
Synthetic promoter design;
Genome-wide CRISPR screens.
❷ Computation and memory
Synthetic transcription platform and gene regulatory
networks in cells.
❸ Response
Regulated diagnostic and therapeutic functions.
❹ Biocontainment
CRISPR-based system in human gut commensal bacteria.
Research interests:
Microbiome engineering, living therapeutics and diagnostics, biosensing, functional metagenomics, genome engineering
