Journals:

  1. Hayashi, N.*, Lai, Y.*, Fuerte-Stone J, Mimee, M., Lu, TK. Cas9-assisted biological containment of a genetically engineered human commensal bacterium and genetic elements. Nature Communications (*co-first author) 15, 2096 (2024).
  2. Chen, W.C.*, Gaidukov, L.*, Lai, Y.*, Wu, M.R., Cao, J., Gutbrod, M.J., Choi, G.C., Utomo, R.P., Chen, Y.C., Wroblewska, L., Kellis, M., Zhang, L., Weiss, R. and Lu, TK. A synthetic transcription platform for programmable gene expression in mammalian cells. Nature Communications (*co-first author) 13, 6167 (2022). Featured in MIT news: A new control system for synthetic genes.
  3. Lai, Y., Hayashi, N., Lu, TK. Engineering human gut commensal Bacteroides thetaiotaomicron with synthetic biology. Current Opinion in Chemical Biology, 70, 102178 (2022).
  4. Lai, Y., Cui, L., Babunovic, G., Fortune, S., Doench, J. G., Lu, TK. High-throughput CRISPR screens to dissect macrophage Shigella interactions. mBio, 12:e02158-21 (2021). 
  5. Lai, Y., Babunovic, G., Cui, L., Dedon, P., Doench, J., Fortune, S., Lu, TK. Illuminating host-mycobacterial interactions with genome-wide CRISPR knockout and CRISPRi screens. Cell Systems, 11(3), 239-251 (2020).
  6. Wang, J., Chew, BL, Lai, Y., Dong, H., Xu, L., Fu, XY., Lin, Z., Shi, PY., Lu, TK, Luo, D., Jaffrey, SR., Dedon, PC. A systems-level mass spectrometry-based technique for accurate and sensitive quantification of the RNA cap epitranscriptome. Nature Protocols (2023).
  7. Inda, E., Jimenez, M., Liu, Q., Phan, N., Ahn, J., Steiger, C., Wentworth, A., Riaz, A., Zirtiloglu, T., Wong, K., Ishida, K., Fabian, N., Jenkins, J., Kuosmanen, J., Madani, W., McNally, R., Lai, Y., Hayward, A., Mimee, M., Nadeau, P., Chandrakasan, A., Traverso, G., Yazicigil, R., Lu, TK. Sub-1.4 cm3 capsule for detecting labile inflammatory biomarkers in situ. Nature (2023).
  8. Liu, X., Inda, M. E., Lai, Y., Lu, TK., & Zhao, X. Engineered Living Hydrogels. Advanced Materials, 2201326 (2022).
  9. Liu, Q., Zirtiloglu, T., Inda, E., Jimenez, M., Lai, Y., Steiger, C., Diamond, E., Traverso, G., Lu, TK, Chandrakasan, AP, Nadeau, P., Yazicigil, RT. Zero-Crossing-Based Bio-Engineered Sensor. IEEE Custom Integrated Circuits Conference (CICC), pp. 1-2 (2021).
  10. Wang, J., Chew, BL, Lai, Y., Dong, H., Xu, L., Balamkundu, S., Cai, WM., Cui, L., Liu, CF., Fu, XY., Lin, Z., Shi, PY., Lu, TK, Luo, D., Jaffrey, SR., Dedon, PC. Quantifying the RNA cap epitranscriptome reveals novel caps in cellular and viral RNA. Nucleic Acids Research 47, no. 20 e130 (2019).
  11. Lai, Y., Xu, Z, Yan, A. A novel regulatory circuit to control indole biosynthesis protects Escherichia coli from nitrosative damages during the anaerobic respiration of nitrate. Environmental Microbiology, 19: 598-610 (2017).
  12. Cao, H., Lai, Y., Bougouffa, S., Xu, Z., & Yan, A. Comparative genome and transcriptome analysis reveals distinctive surface characteristics and unique physiological potentials of Pseudomonas aeruginosa ATCC 27853. BMC Genomics, 18(1), 459 (2017).
  13. Xiao, M., Lai, Y., Sun, J., Chen, G., & Yan, A. Transcriptional regulation of the outer membrane porin gene ompW reveals its physiological role during the transition from the aerobic to the anaerobic lifestyle of Escherichia coli. Frontiers in Microbiology, 7, 799 (2016).
  14. Li, L., He, L., Lai, Y., Shao, Y., & Chen, F. Cloning and functional analysis of the Gβ gene Mgb1 and the gene Mgg1 in Monascus ruber. Journal of Microbiology, 52(1), 35-43 (2014).
  15. Lai, Y., Wang, L., Qing, L., & Chen, F. Effects of cyclic AMP on development and secondary metabolites of Monascus ruber M7. Letters in Applied Microbiology, 52(4), 420-426 (2011).

Book chapters:

  1. Shan, Y.*, Lai, Y.*, & Yan, A. Metabolic reprogramming under microaerobic and anaerobic conditions in bacteria. Reprogramming Microbial Metabolic Pathways, Springer Netherlands, 159-179 (2012). (* co-first author)

Patents:

  1. Lu TK, Lai Y. High-Throughput Genetic Screening. (WO 2021/064655; PCT/IB2020/059240).
  2. Lu TK, Inda E, Lenneman B, Lai Y. Engineering Probiotic Bacteria for Treating Celiac Disease (Serial No.: 63/161,171; MIT Case No.: 22771)